Expression of Gstt1 in Type 2 Diabetic Retinopathy Patients
| Autor: | Tasnim Farasat, Saima Sharif, Maha Maqsood, Malik Shah Jahan, Farkhanda Manzoor, Shagufta Naz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Disease 03 medical and health sciences chemistry.chemical_compound Internal medicine Diabetes mellitus Genetics medicine Humans Molecular Biology Glutathione Transferase Regulation of gene expression 0303 health sciences Retina Diabetic Retinopathy business.industry 030302 biochemistry & molecular biology Case-control study Type 2 Diabetes Mellitus Diabetic retinopathy Glutathione medicine.disease medicine.anatomical_structure Endocrinology chemistry Diabetes Mellitus Type 2 Gene Expression Regulation Case-Control Studies business |
| Zdroj: | Critical reviews in eukaryotic gene expression. 29(1) |
| ISSN: | 1045-4403 |
| Popis: | Type 2 diabetes mellitus (T2DM) is the most common metabolic and multifactorial disease in which both genetic and environmental factors are involved. In diabetes, the defects in the cellular metabolism result in higher levels of free radicals. These radicals react with other vital cellular molecules, which are responsible in diabetes side effects and known as diabetic retinopathy (DR), a disease of the retina that results in impairment or loss of vision. In the present study, we investigated the expression of glutathione S-transferases class theta 1 (GSTT1) in type 2 DR subjects. Highly significant differences (P ≤ 0.05) were observed in GSST1 expression in DR patients compared with diabetic and control groups. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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