Comparative analysis of dermal collagen and lipids in cereblon ablated mice using a multimodal nonlinear optical system

Autor:	Chang Woo Park, Seungje Jeon, Seong‐Hoon Kwon, Jun‐Hyung Jung, Jung Eun Seol, Chul‐Seung Park, Steve K. Cho, Do‐Kyeong Ko
Rok vydání:	2022
Předmět:	General Engineering General Physics and Astronomy General Materials Science General Chemistry General Biochemistry Genetics and Molecular Biology
Zdroj:	Journal of Biophotonics. 16
ISSN:	1864-0648 1864-063X
DOI:	10.1002/jbio.202200139
Popis:	By utilizing a multimodal nonlinear optical system that combines coherent anti-Stokes Raman scattering and second harmonic generation to investigate biological characteristics of dermal tissues ex vivo, we demonstrate the potential feasibility of using this optical approach as a powerful new investigative tool for future biomedical research. For this study, our optical system was utilized for the first time to analyze lipid and collagen profiles in cereblon knockout (KO) mouse skin, and we were able to discover significant alterations in the number of carbon-carbon double bonds (wild-type vs. cereblon KO; N
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919aa16904a09136c4547e0d8f8e8d79 https://doi.org/10.1002/jbio.202200139 Zobrazit plný text záznamu Plný text