Trio Act of Boronolectin with Antibiotic-Metal Complexed Macromolecules toward Broad-Spectrum Antimicrobial Efficacy
| Autor: | Yung Pin Chen, Alan W. Decho, Chuanbing Tang, Tianyu Zhu, Parasmani Pageni, Mitzi Nagarkatti, Marpe Bam, Peng Yang |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Boron Compounds
Lipopolysaccharide medicine.drug_class Macromolecular Substances Polymers Antibiotics Apoptosis 02 engineering and technology 010402 general chemistry medicine.disease_cause 01 natural sciences Article Microbiology chemistry.chemical_compound Mice Immune system medicine Animals Cells Cultured Microbial Viability biology Bacteria Molecular Structure Monosaccharides Pathogenic bacteria 021001 nanoscience & nanotechnology Antimicrobial medicine.disease biology.organism_classification Hemolysis 0104 chemical sciences Anti-Bacterial Agents Mice Inbred C57BL Infectious Diseases chemistry Biochemistry Metals Female Peptidoglycan 0210 nano-technology Spleen |
| Popis: | Bacterial infections, particularly by Gram-negative pathogens, have become a serious threat to global healthcare due to the diminishing effectiveness of existing antibiotics. We report a nontraditional therapy to combine three components in one macromolecular system, in which boronic acid adheres to peptidoglycan or lipopolysaccharide via boron-polyol based boronolectin chemistry, cationic metal polymer frameworks interact with negatively charged cell membranes, and β-lactam antibiotics are reinstated with enhanced vitality to attack bacteria via evading the detrimental enzyme-catalyzed hydrolysis. These macromolecular systems exhibited high efficacy in combating pathogenic bacteria, especially Gram-negative strains, due to synergistic effects of multicomponents on interactions with bacterial cells. In vitro and in vivo cytotoxicity and hemolysis evaluation indicated that these multifunctional copolymers did not induce cell death by apoptosis, as well as did not alter the phenotypes of immune cells and did not show observable toxic effect on red blood cells. |
| Databáze: | OpenAIRE |
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