Nocturnal Hypoglycemia – The Main Indication for Insulin Pump Therapy in Adulthood
| Autor: | Ivana Pavlić Renar, Maja Baretić, Ivana Kraljević |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Male Insulin pump Adult Pediatrics medicine.medical_specialty Croatia medicine.medical_treatment lcsh:Medicine 030209 endocrinology & metabolism Hypoglycemia prevention and control Hypoglycemia type 1 diabetes insulin pump therapy indication Young Adult 03 medical and health sciences 0302 clinical medicine Diabetes mellitus medicine Insulin – pump administration and dosage Humans Hypoglycemic Agents Insulin 030212 general & internal medicine Young adult Retrospective Studies Glycemic Glycated Hemoglobin Diabetes mellitus type 1 – complications business.industry lcsh:R nutritional and metabolic diseases General Medicine medicine.disease Insulin infusion systems Surgery Diabetes Mellitus Type 1 Female business Polyneuropathy Retinopathy |
| Zdroj: | Acta Clinica Croatica, Vol 55., Iss 1., Pp 93-98 (2016) |
| ISSN: | 1333-9451 0353-9466 |
| Popis: | The aim was to determine which adult type 1 diabetic patient receiving multiple daily injection therapy is the most appropriate candidate for insulin pump therapy, while taking into consideration limited insulin pump affordability in Croatia. A total of 145 type 1 diabetic patients (52% diagnosed in adult age) were monitored at the Department of Endocrinology, Clinical Department of Internal Medicine, Zagreb University Hospital Center from 2009 to 2014. Twenty-one patients started insulin pump therapy in adulthood (seven men and 14 women, median age 27). Five patients had chronic complications (retinopathy in two, polyneuropathy in one, and both nephropathy and retinopathy in two patients). The median HbA1c at the initiation of pump therapy was 6.95% versus 6.5% after 1 year of pump therapy. Patients were stratified according to indications for insulin pump therapy (frequent and/or severe hypoglycemia, specific lifestyle, having not reached glycemic goals despite adherence/labile diabetes, and preconception). Patients could meet more than one criterion. Initially, the occurrence of hypoglycemia was analyzed by 6-day continuous glucose monitoring, while re-evaluation was done after collecting history data at 1 year ± 3 months. Initially, all patients had a median of 5 hypoglycemias/6 days (30% nocturnal) versus 1 hypoglycemia/6 days (without nocturnal) after 1 year. The Wilcoxon signed-rank test yielded a statistically significant difference in hypoglycemic events, nocturnal hypoglycemia and HbA1c. Patients commencing insulin pump therapy due to hypoglycemia initially had median HbA1c of 6.7% with 7 hypoglycemia/6 days (50% nocturnal). After one year, median HbA1c was 6% with 1 hypoglycemia/6 days (without nocturnal). In conclusion, the main indication for insulin pump therapy in adults is the frequency of hypoglycemia, especially nocturnal ones. |
| Databáze: | OpenAIRE |
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