Acute coumaphos organophosphate exposure in the domestic dogs: Its implication on haematology and liver functions
| Autor: | M.O. Abatan, Olufunke Eunice Ola-Davies, Ademola Adetokunbo Oyagbemi, O. I. Azeez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Veterinary medicine Hematology lcsh:Veterinary medicine General Veterinary business.industry Acaricide Organophosphate Coumaphos 010501 environmental sciences 01 natural sciences 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Blood chemistry Internal medicine Medicine lcsh:SF600-1100 Tick Control Livestock 030212 general & internal medicine Liver functions business 0105 earth and related environmental sciences |
| Zdroj: | International Journal of Veterinary Science and Medicine, Vol 6, Iss 1, Pp 103-112 (2018) |
| ISSN: | 2314-4599 |
| Popis: | Indiscriminate use of organophosphate acaricides especially among livestock and dog owners in the control of ticks and other ectoparasites has taken a worrisome dimension. In the present study, we investigated, the effects of acute dermal exposure in the form of acaricides baths of coumaphos at different concentrations on the haematology, blood pressure and liver functions in local mongrel dogs.Twenty-four, male mongrel dogs of about 8 months of age with an average weight of 9.88 ± 0.4 kg were used for the study. The dogs were divided into four groups consisting of six dogs per group. Group A (control) was bathed with ordinary water, while group B was bathed with the recommended concentration of 0.016% (160 ppm) Coumaphos in water. Groups C and D were bathed with 10 and 20 times the recommended dose (1600 ppm and 3200 ppm), respectively.Significant leucopenia, increased plasma urea and decreased low density lipoprotein (LDL) values were observed at 8 h post exposure, which worsened with time. At 24 and 36 hrs post exposure, normochromic normocytic anaemia, pan leucopenia, bloody diarrhoea, retching, vomiting and paddling were observed in affected animals. Post mortem examination revealed severe lungs, liver and stomach congestion. Multifocal areas of necrosis in the liver and kidney, serosal and mucosal haemorrhages and haemorrhagic meningitis were also observed.The use of excessively high concentration of organophosphate as acaricides bath is associated with severe anticholinesterase poisoning, which may result in death of affected animals. Keywords: Acaricides bath, Anaemia, Coumaphos, Dogs, Haematotoxicity, Organophosphate |
| Databáze: | OpenAIRE |
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