Versatile composite hydrogels for drug delivery and beyond
| Autor: | Yi Hua Chiang, Teh Min Hu, Meng Ju Wu, Wei Chin Hsu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Composite number Biomedical Engineering chemistry.chemical_compound Drug Delivery Systems Animals General Materials Science Organosilicon Compounds Bovine serum albumin Porosity biology Rhodamines technology industry and agriculture Hydrogels Serum Albumin Bovine General Chemistry General Medicine Nuclear magnetic resonance spectroscopy Silanes Methylene Blue Drug Liberation Chemical engineering chemistry Doxorubicin Siloxane Drug delivery Self-healing hydrogels biology.protein Cattle Fluorescein Absorption (chemistry) |
| Zdroj: | Journal of materials chemistry. B. 8(38) |
| ISSN: | 2050-7518 |
| Popis: | Hydrogels have extended applications across multiple fields. A novel hydrogel material is often evaluated for its properties and applications in either a wet or dry state, but not both. In this study, we investigated a protein-based, composite hydrogel system in both its wet and dry states. Bovine serum albumin (BSA) was used as the hydrogel base. With the assistance of organosilanes, BSA solutions became hydrogels under facile reaction conditions. In the first part, the wet gel was prepared in situ in a syringe; upon injecting through a needle, the gel retained its structure. The use of the nascent gel system as an injectable drug-delivery vehicle is of particular interest. We therefore developed a microplate platform that allows a "one-plate" study-i.e. gel preparation, payload loading and release-all being performed in a single plate. This one-plate method further enables a systematic study of various controlling parameters for drug release. For example, we can tune the release rate by simply adjusting the phosphate content in the hydrogel formulation. Besides, for low-releasing compounds, the release profile was also tunable while using the one-plate method. In the second part, we further demonstrate the versatility of our composite hydrogels. By simply varying the feed ratio of two organosilanes, (3-mercaptopropyl)methyldimethoxysilane and (3-mercaptopropyl)trimethoxysilane, and phosphate concentrations, dry gels exhibiting various absorption capacities towards water, organic solvents, and oil can be prepared. Further characterizations using SEM and 29Si NMR spectroscopy revealed porous structures and hybrid siloxane bridges within the composite material. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|