Gastrointestinal cytomegalovirus disease secondary to measles in an immunocompetent infant: A case report
| Autor: | Jian-Ming Song, Xiao-Peng Ma, Qing-Hua Yang, Yu Zou, Dongling Dai, Da-Ming Bai, Sixi Liu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Diarrhea
Ganciclovir Gastrointestinal medicine.medical_treatment Congenital cytomegalovirus infection Cytomegalovirus Hematopoietic stem cell transplantation Measles Serology 03 medical and health sciences 0302 clinical medicine Case report medicine biology business.industry Gastroenterology Infant virus diseases General Medicine medicine.disease 030220 oncology & carcinogenesis Immunology biology.protein 030211 gastroenterology & hepatology medicine.symptom Differential diagnosis Antibody business medicine.drug |
| Zdroj: | World Journal of Gastroenterology |
| ISSN: | 1007-9327 |
| DOI: | 10.3748/wjg.v27.i15.1655 |
| Popis: | Background Gastrointestinal cytomegalovirus (CMV) disease occurs commonly in immunocompromised/immunodeficient patients with advanced human immunodeficiency virus infection, neoplasm, solid organ transplantation, hematopoietic stem cell transplantation, or treatment with immunosuppressants, but is rarely reported in association with measles infection. Case summary We describe a case of extensive gastrointestinal CMV disease secondary to measles infection in a 9-mo-old boy who presented with persistent fever and bloody diarrhea. His condition was improved after ganciclovir treatment. Serological analysis of CMV showed negative immunoglobulin (Ig) M and positive IgG. Blood CMV-DNA was 9.26 × 103 copies/mL. The diagnosis of gastrointestinal CMV disease was confirmed by histopathological findings of intranuclear and intracytoplasmic inclusions and Owl's eye inclusion. This case highlights the differential diagnosis and histopathological characteristics of gastrointestinal CMV infection and laboratory tests. Conclusion Extensive gastrointestinal CMV lesions can be induced by the immune suppression secondary to measles infection. Rational, fast, and effective laboratory examinations are essential for suspected patients. |
| Databáze: | OpenAIRE |
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