Reuse of Molecules for Glioblastoma Therapy
| Autor: | Renee Read, Donatien K Toukam, Soma Sengupta, Abigail Koehler, Xiaoyang Qi, Aniruddha Karve, David R. Plas, Vaibhavkumar S. Gawali, Daniel Pomeranz Krummel, Jack L. Arbiser, Atsuo T. Sasaki, Laura Kallay, Pankaj B. Desai, Debanjan Bhattacharya |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology Surgical resection medicine.medical_specialty Standard of care CellCept® letrozole medicine.medical_treatment Brain tumor Pharmaceutical Science lcsh:Medicine lcsh:RS1-441 saposin C S6K1 inhibitors Review lcsh:Pharmacy and materia medica 03 medical and health sciences imipramine blue 0302 clinical medicine Internal medicine Drug Discovery medicine brain cancer Temozolomide Treatment regimen business.industry Visudyne® lcsh:R glioblastoma medicine.disease Radiation therapy 030104 developmental biology 030220 oncology & carcinogenesis Concomitant Molecular Medicine business medicine.drug Glioblastoma |
| Zdroj: | Pharmaceuticals Pharmaceuticals, Vol 14, Iss 99, p 99 (2021) |
| ISSN: | 1424-8247 |
| Popis: | Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor. The current standard of care for GBM is the Stupp protocol which includes surgical resection, followed by radiotherapy concomitant with the DNA alkylator temozolomide; however, survival under this treatment regimen is an abysmal 12–18 months. New and emerging treatments include the application of a physical device, non-invasive ‘tumor treating fields’ (TTFs), including its concomitant use with standard of care; and varied vaccines and immunotherapeutics being trialed. Some of these approaches have extended life by a few months over standard of care, but in some cases are only available for a minority of GBM patients. Extensive activity is also underway to repurpose and reposition therapeutics for GBM, either alone or in combination with the standard of care. In this review, we present select molecules that target different pathways and are at various stages of clinical translation as case studies to illustrate the rationale for their repurposing-repositioning and potential clinical use. |
| Databáze: | OpenAIRE |
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