Synthesis and antiinflammatory activity of some 1,2,3- and 1,2,4-triazolepropionic acids
| Autor: | E. Kurchacova, Gust Nichols, Barrie M. Phillips, Robert T. Buckler, Harold E. Hartzler |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Stereochemistry Triazole Anti-Inflammatory Agents chemistry.chemical_element Triazoles Ring (chemistry) Nitrogen Arthritis Experimental Rats Pleural Effusion chemistry.chemical_compound Structure-Activity Relationship chemistry Drug Discovery Phenylbutazone medicine Molecular Medicine Animals Propionates medicine.drug |
| Zdroj: | Journal of medicinal chemistry. 21(12) |
| ISSN: | 0022-2623 |
| Popis: | All possible "nonadjacent" phenyltriazolepropionic acids were synthesized and tested for antiinflammatory activity. Two of the isomers displayed activity approximately equal to phenylbutazone: the 4-phenyl-1,2,3,-triazole-2-propionic acid (7) and its reverse counterpart, 2-phenyl-1,2,3-triazole-4-propionic acid (6). The other five isomers were inactive. Since these seven acids are geometrically congruent and possess similar lipophilic characters, antiinflammatory activity must depend on some property that is a function of how the carbon and nitrogen atoms are arranged in the triazole ring. |
| Databáze: | OpenAIRE |
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