Enhancement of hydrosolubility and in vitro antiproliferative properties of chalcones following encapsulation into β-cyclodextrin/cellulose-nanocrystal complexes

Autor: Benjamin Rioux, Catherine Fagnère, Robert Granet, Bertrand Liagre, Aurélie Laurent, Gautier M.A. Ndong-Ntoutoume, Yves Champavier, Aurélie Gamond, Christelle Pouget, Vincent Sol, Aline Pinon
Přispěvatelé: Laboratoire de Chimie des Substances Naturelles (LCSN), Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), PEIRENE (PEIRENE), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Le Mans Université (UM), Service Commun de Résonance Magnétique Nucléaire (RMN), Université de Limoges (UNILIM)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Chalcone
[SDV]Life Sciences [q-bio]
Clinical Biochemistry
Pharmaceutical Science
Nanoparticle
Ionic bonding
[SDV.CAN]Life Sciences [q-bio]/Cancer
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
01 natural sciences
Biochemistry
chemistry.chemical_compound
Chalcones
Drug Discovery
Humans
[CHIM]Chemical Sciences
Cellulose
Molecular Biology
ComputingMilieux_MISCELLANEOUS
chemistry.chemical_classification
Cyclodextrin
010405 organic chemistry
[CHIM.ORGA]Chemical Sciences/Organic chemistry
beta-Cyclodextrins
Organic Chemistry
Cationic polymerization
Hydrosolubilization of hydrophobic drugs
Combinatorial chemistry
In vitro
0104 chemical sciences
β-Cyclodextrin/cellulose nanocrystals
010404 medicinal & biomolecular chemistry
[CHIM.POLY]Chemical Sciences/Polymers
chemistry
Nanocrystal
Prostate and colorectal cancer cell lines
Molecular Medicine
Nanoparticles
Zdroj: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2019, 29 (15), pp.1895-1898. ⟨10.1016/j.bmcl.2019.05.056⟩
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2019.05.056⟩
Popis: International audience; This paper describes the preparation of two chalcone/β-cyclodextrin/cellulose-nanocrystals complexes and thestudy of their antiproliferative activities against two colorectal and two prostatic cancer cell lines. The aim of thiswork was to enhance hydrosolubility of chalcones thanks to the hydrophilic character of cellulose nanocrystals.These latter were linked, through ionic interactions, to a cationic derivative of β-cyclodextrins whose lipophiliccavity allowed the encapsulation of hydrophobic chalcones: 3-hydroxy-3′,4,4′,5′-tetramethoxychalcone (1) and3′,4,4′,5′-tetramethoxychalcone (2). First, we showed that encapsulation allowed hydrosolubilization of chalcones.Then, chalcone/β-cyclodextrin/cellulose-nanocrystals complexes demonstrated enhanced in vitro antiproliferativeactivities, compared to the corresponding free-chalcones.
Databáze: OpenAIRE
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