Cleavage factor Im 25 as a potential biomarker for prognosis of colorectal cancer
| Autor: | Yubo, Cai, Zequn, Chen, Yutong, Liang, Yuehua, Liao, Yuanwei, Wu, Junqiang, Huang, Zhizhen, Huang, Ronggang, Li, Jiewei, Chen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Translational Cancer Research |
| ISSN: | 2219-6803 2218-676X |
| DOI: | 10.21037/tcr-21-1441 |
| Popis: | Background Cleavage factor Im 25 (CFIm25) affects the prognosis and progression of cancer by regulating alternative polyadenylation; however, its role in colorectal cancer remains unclear. Methods A standard EnVision tissue microarray was used to evaluate the expression of CFIm25 by immunohistochemistry in 363 patients with colorectal cancer. The correlation between CFIm25 expression and clinicopathological characteristics was analyzed using the χ2 test. Univariate analysis was used to study the relationship between clinicopathological characteristics and patient prognosis. Multivariate analysis was performed using the Cox regression model to identify independent prognostic factors for patients with colorectal cancer. Results Statistical analysis revealed that CFIm25 expression was significantly associated with vascular invasion (P=0.000), serous invasion (P=0.007), pT stage (P=0.016), and clinical stage (P=0.007). Age, vascular invasion, nerve invasion, serosal invasion, differentiation, clinical stage, recurrence, and CFIm25 expression were significantly correlated with the survival time of colorectal cancer patients (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|