The effects of prior calcium channel blocker therapy on creatine kinase-MB levels after percutaneous coronary interventions
| Autor: | Ilyas Atar, Alp Aydinalp, Mehmet Emin Korkmaz, Asli Atar, Bülent Özin, Aylin Yildirir, Öykü Gülmez, Haldun Muderrisoglu |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Percutaneous Endocrinology Diabetes and Metabolism medicine.medical_treatment Administration Oral Coronary Artery Disease Creatine percutaneous coronary interventions Coronary artery disease Necrosis chemistry.chemical_compound Internal medicine medicine Creatine Kinase MB Form Humans Pharmacology (medical) Angioplasty Balloon Coronary Original Research Aged calcium channel blockers business.industry Myocardium Calcium channel Public Health Environmental and Occupational Health Case-control study Percutaneous coronary intervention Hematology General Medicine Blood flow Middle Aged medicine.disease Vascular Health and Risk Management Treatment Outcome chemistry myonecrosis Case-Control Studies Conventional PCI Cardiology Female Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Vascular Health and Risk Management Scopus-Elsevier |
| ISSN: | 1178-2048 |
| DOI: | 10.2147/vhrm.s2998 |
| Popis: | Oyku Gulmez, Ilyas Atar, Bülent Ozin, Mehmet Emin Korkmaz, Aslı Atar, Alp Aydinalp, Aylin Yildirir, Haldun MuderrisogluBaskent University Faculty of Medicine, Department of Cardiology, Ankara, TurkeyBackground: Use of intracoronary calcium channel blockers (CCBs) during percutaneous coronary intervention (PCI) has been shown to have favorable effects on coronary blood flow. We aimed to investigate the effects of CCBs administrated perorally on creatine kinase-MB (CK-MB) levels in patients undergoing elective PCI.Methods: A total of 570 patients who underwent PCI were evaluated for CK-MB elevation. Patients who were on CCB therapy when admitted to the hospital constituted the CCB group. No CCBs were given to the rest of the patients during the periprocedural period and these patients served as the control group. Blood samples for CK-MB were obtained before and at 6 h, 24 h, and 36 h after the procedure.Results: 217 patients were in the CCB group (mean age 60.2 ± 9.3 years, 162 males), and 353 were in the control group (mean age 60.0 ± 10.1 years, 262 males). CK-MB levels increased above the normal values in 41 patients (18.9%) of the CCBs group and in 97 patients (27.5%) of the control group (p = 0.02). Median CK-MB levels were significantly higher in the control group for all studied hours (for all p |
| Databáze: | OpenAIRE |
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