Coatings in food contact materials: Potential source of genotoxic contaminants?
| Autor: | Luc Verschaeve, Birgit Mertens, S. Fraselle, M. Van Bossuyt, E. Van Hoeck, Tamara Vanhaecke, Marie-Noelle Blaude, Vera Rogiers |
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| Přispěvatelé: | Experimental in vitro toxicology and dermato-cosmetology, Faculty of Medicine and Pharmacy, Pharmaceutical and Pharmacological Sciences, Connexin Signalling Research Group, Vriendenkring VUB |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Food contact materials Food Contamination Context (language use) Toxicology medicine.disease_cause ECHA Database 03 medical and health sciences Human health 0404 agricultural biotechnology Prioritization strategy medicine Humans Potential source Biology Mutagenicity Tests Pharmacology. Therapy Food Packaging 04 agricultural and veterinary sciences General Medicine Contamination Structure-activity relationship 040401 food science Food packaging 030104 developmental biology Consumer Product Safety in silico DNA damage Environmental science Human medicine Biochemical engineering Mutagenicity Test Genotoxicity Mutagens Food Science |
| Zdroj: | Food and chemical toxicology |
| ISSN: | 0278-6915 |
| Popis: | Up till now, no harmonized EU regulation exists on chemicals used in coatings for food contact materials (FCM). Therefore, these substances need to comply with the general provisions of EU Regulation 1935/2004 and, if present, with national legislation. Different inventory lists of compounds that might be present in coatings are available, but for hundreds of these substances, the potential human health impact of their use in FCM coatings has not (recently) been evaluated. Since detailed evaluation of all compounds is not feasible, a pragmatic approach was developed to identify substances with a potential concern for human health. First, an inventory was assembled containing all substances potentially used in coatings. Afterwards, the genotoxic potential of the non-evaluated substances was predicted in silico using two structure-activity relationship (SAR) software programs. For substances yielding structural alerts in both models, genotoxicity data were collected from previous European evaluations in a non-FCM context and from the European CHemicals Agency (ECHA) website. In total, 53 substances were identified as genotoxic in both in silico models, of which ten were considered to be of high concern. For most of the substances, additional toxicological information is needed. |
| Databáze: | OpenAIRE |
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