Polysialylation controls dendritic cell trafficking by regulating chemokine recognition
| Autor: | Richard Imre, Reinhold Förster, Martina Mühlenhoff, Gary R. Chaffee, Christine Moussion, Larry G. Williams, Ingrid de Vries, Karl Mechtler, Brian F. Volkman, Michael Sixt, Andrew J. Phillips, Christopher T. Veldkamp, Asolina Braun, Richard J. Payne, Deni Taleski, Rita Gerardy-Schahn, Friedrich Freiberger, Eva Kiermaier |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Receptors CCR7 Chemokine Glycosylation Cell Bone Marrow Cells C-C chemokine receptor type 7 Biology Ligands Article Mice 03 medical and health sciences Chemokine receptor medicine Animals Receptor Multidisciplinary Chemokine CCL21 Polysialic acid Chemotaxis Dendritic Cells Dendritic cell Mice Mutant Strains Cell biology Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Immunology Sialic Acids biology.protein Lymph Nodes Protein Processing Post-Translational CCL21 |
| Zdroj: | Science. 351:186-190 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | A chemokine's sugary release As immune cells survey the body for pathogens, they circulate through the blood and migrate through the lymphatic system. The latter route allows for tissues and lymph nodes—the central hubs of the immune system—to communicate. Kiermaier et al. reveal the importance of the monosaccharide sialic acid in keeping immune cells in motion. Multiple sialic acids decorate the surface CCR7 on immune cells. CCR7 recognizes proteins called chemokines, which direct where cells move in the body. Sialic acids on CCR7 release one such chemokine present on lymph node endothelial cells from an inhibited state, allowing immune cells to enter lymph nodes. Science , this issue p. 186 |
| Databáze: | OpenAIRE |
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