Baseline laboratory parameters for preliminary diagnosis of COVID-19 among children: a cross-sectional study
| Autor: | Dejan Dobrijević, Jasmina Katanić, Maša Todorović, Biljana Vučković |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Thrombocytosis Adolescent L-Lactate Dehydrogenase Leukocytosis SARS-CoV-2 COVID-19 Alanine Transaminase General Medicine Control group selection C-Reactive Protein COVID-19 Testing Cross-Sectional Studies Laboratory diagnosis Lymphopenia Humans Female Aspartate Aminotransferases Child Biomarkers Children with COVID Hyponatremia Retrospective Studies |
| Zdroj: | Sao Paulo Medical Journal, Volume: 140, Issue: 5, Pages: 691-696, Published: 12 AUG 2022 Sao Paulo Medical Journal v.140 n.5 2022 São Paulo medical journal Associação Paulista de Medicina instacron:APM Sao Paulo Medical Journal, Issue: ahead, Published: 12 AUG 2022 Sao Paulo Medical Journal n.ahead 2022 |
| ISSN: | 1806-9460 |
| Popis: | BACKGROUND: Clinical judgment of initial baseline laboratory tests plays an important role in triage and preliminary diagnosis among coronavirus disease 2019 (COVID-19) patients. OBJECTIVES: To determine the differences in laboratory parameters between COVID-19 and COVID-like patients, and between COVID-19 and healthy children. Additionally, to ascertain whether healthy children or patients with COVID-like symptoms would form a better control group. DESIGN AND SETTING: Cross-sectional study at the Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia. METHODS: A retrospective study was conducted on 42 pediatric patients of both sexes with COVID-19. Hematological parameters (white blood cell count, absolute lymphocyte count and platelet count) and biochemical parameters (natremia, kalemia, chloremia, aspartate aminotransferase [AST], alanine aminotransferase [ALT], lactate dehydrogenase [LDH] and C-reactive protein [CRP]) were collected. The first control group was formed by 80 healthy children and the second control group was formed by 55 pediatric patients with COVID-like symptoms. RESULTS: Leukocytosis, lymphopenia, thrombocytosis, elevated systemic inflammatory index and neutrophil-lymphocyte ratio, hyponatremia, hypochloremia and elevated levels of AST, ALT, LDH and CRP were present in COVID patients, in comparison with healthy controls, while in comparison with COVID-like controls only lymphopenia was determined. CONCLUSIONS: The presence of leukocytosis, lymphopenia, thrombocytosis, elevated systemic inflammatory index and neutrophil-lymphocyte ratio, hyponatremia, hypochloremia and elevated levels of AST, ALT, LDH and CRP may help healthcare providers in early identification of COVID-19 patients. Healthy controls were superior to COVID-like controls since they provided better insight into the laboratory characteristics of children with novel betacoronavirus (SARS-CoV-2) infection. |
| Databáze: | OpenAIRE |
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