Metastatic castration-resistant prostate cancer: a current view on drug therapy and alternative tumor cell regulation
| Autor: | R. A. Gafanov, S. V. Garmash, I. B. Kravtsov, S. V. Fastovets |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2018 |
| Předmět: |
business.industry
Urology medicine.disease Pathogenesis Androgen receptor Prostate cancer Oncology Castration Resistance Nephrology androgen receptor Cancer research Medicine castration-resistant prostate cancer Radiology Nuclear Medicine and imaging Surgery Treatment resistance business pi3k PI3K/AKT/mTOR pathway |
| Zdroj: | Onkourologiâ, Vol 14, Iss 1, Pp 107-116 (2018) |
| ISSN: | 1996-1812 1726-9776 |
| Popis: | Prostate cancer (PC) is one of the most common causes of death from malignant neoplasms in men in many countries around the world. Transmission of the signal in the androgenic axis of regulation is crucial for the development and progression of PC. Despite the constant dependence on androgen receptor signals in castration resistance, the use of new anti-androgenic drugs invariably leads to the stability of the ongoing treatment. The interaction of androgen receptor and alternative (phosphoinositide-3-kinases, PI3K) pathways in the regulation of cells can be one of the mechanisms of resistance to treatment. In this article, we describe current treatments for metastatic castration-resistant PC and the possible role of the PI3K pathway in the pathogenesis and progression of PC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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