Acute regulation of adiponectin by free fatty acids
| Autor: | Jeff Breu, Karin Ljungquist, Polyxeni Koutkia, Elizabeth L Bernstein, Steven K. Grinspoon, Bridget Canavan |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Blood Glucose Male Acipimox medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Fatty Acids Nonesterified Placebo Endocrinology Oral administration Internal medicine medicine Humans Insulin Longitudinal Studies Pancreatic hormone Hypolipidemic Agents Adiponectin business.industry Healthy subjects nutritional and metabolic diseases Proteins Fasting Middle Aged Pyrazines Intercellular Signaling Peptides and Proteins lipids (amino acids peptides and proteins) Animal studies business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Metabolism: clinical and experimental. 53(6) |
| ISSN: | 0026-0495 |
| Popis: | Little is known about the acute regulation of adiponectin in humans. In animal studies, adiponectin increases the clearance of free fatty acids (FFA) from the circulation by increasing skeletal uptake and oxidation of lipid, thereby regulating the FFA concentration. However, it is unknown if FFA regulate adiponectin. The aim of the present study was to investigate the effect of an acute reduction in free fatty acids on adiponectin concentration in healthy subjects. Ten normal male subjects were admitted for 2 inpatient visits and randomized to receive either acipimox (500 mg orally at 2 am and again at 6 am) or placebo on the first visit and vice versa on the second visit. Adiponectin, FFA, insulin and glucose were measured at 7:45 am. FFA concentrations were significantly lower after acipimox than placebo administration (0.08 +/- 0.02 mEq/L v 0.35 +/- 0.53 mEq/L, P |
| Databáze: | OpenAIRE |
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