Intramedullary spinal cord tumours - a single Centre, 10-year review of clinical and pathological outcomes
| Autor: | C Derham, Atul Tyagi, Paul Chumas, Oliver Richards, Edward Goacher, Debasish Pal |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Neurological function Central nervous system Intramedullary spinal cord law.invention Intramedullary rod 03 medical and health sciences 0302 clinical medicine law medicine Humans Spinal Cord Neoplasms Pathological Retrospective Studies business.industry General Medicine Surgery Single centre medicine.anatomical_structure Treatment Outcome Ependymoma 030220 oncology & carcinogenesis Neurology (clinical) Neoplasm Recurrence Local business 030217 neurology & neurosurgery |
| Zdroj: | British journal of neurosurgery. 35(2) |
| ISSN: | 1360-046X |
| Popis: | Intramedullary spinal cord tumours are relatively rare tumours of the central nervous system. Surgical outcomes are affected by many variables, including pre-operative neurological function, tumour histology and extent of resection. Emphasis remains on surgical treatment due to limited adjunctive therapeutic options and poor drug penetration.To identify clinically relevant predictors of progression free survival by retrospectively analysing the extent of resection, pre- and post-operative neurological function and histology in intramedullary spinal cord tumours from a single neurosurgical centre over 10 years.Forty-three adult cases were identified from a surgical database. Variables collected included pre-and post-operative Frankel Grade and Modified McCormick Scale assessments, tumour histology, extent of resection and length of follow up. Chi-Squared, Kaplan-Mier Survival and Mann-WhitneyEpendymoma (41.9%) and haemangioblastoma (14.0%) were the commonest tumour histologies. In total, 17 different histological tumours were identified in the series. There was a statistically significant relationship between identification of the tumour plane and extent of resection (Tumour plane and the extent of tumour resection are significant determinants of progression-free survival. Ependymoma, whilst being the commonest histology in our series were also the most resectable. Whilst complete resection reduces the rate of recurrence, tumour grade is the most important predictor of outcome. Given the importance of the extent of resection, and following a similar trend to other low volume pathologies, these tumours should only be tackled by neurosurgeons with experience in their resection. |
| Databáze: | OpenAIRE |
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