Synthesis of Benzofuranones via Palladium-Catalyzed Intramolecular Alkoxycarbonylation of Alkenylphenols
| Autor: | Ivana Fleischer, Vera Hirschbeck |
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| Rok vydání: | 2017 |
| Předmět: |
Reaction conditions
010405 organic chemistry Chemistry Organic Chemistry chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound Polymerization Intramolecular force Functional group Carbonylation Palladium |
| Zdroj: | Chemistry (Weinheim an der Bergstrasse, Germany). 24(12) |
| ISSN: | 1521-3765 |
| Popis: | Herein, a new catalytic system to synthesize benzofuranones is reported. A palladium-catalyzed intramolecular alkoxycarbonylation is employed to generate 3-substituted-benzofuran-2(3H)-ones from alkenylphenols under mild reaction conditions, linked to an ex situ formation of CO from N-formylsaccharin. The carefully chosen catalytic system enables an efficient reaction with a novel functional group tolerance, despite the high polymerization tendency of the starting material. |
| Databáze: | OpenAIRE |
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