Influence of menopausal status and use of hormone replacement therapy on radiation dose from mammography in routine breast screening
| Autor: | C. J. Whitaker, Keith Faulkner, C M Kelly, E. C. Stamp |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
medicine.medical_specialty genetic structures Hormone Replacement Therapy medicine.medical_treatment Mammary gland Breast Neoplasms Radiation Dosage Surveys and Questionnaires medicine Breast screening Mammography Humans Radiology Nuclear Medicine and imaging Aged Gynecology Aged 80 and over Routine screening medicine.diagnostic_test business.industry Obstetrics Radiation dose Hormone replacement therapy (menopause) General Medicine Middle Aged medicine.disease eye diseases Menopause medicine.anatomical_structure Female sense organs Hormone therapy business |
| Zdroj: | The British journal of radiology. 79(943) |
| ISSN: | 1748-880X |
| Popis: | Menopausal status and hormone replacement therapy (HRT) cause alterations in breast structure which can affect mammographic image quality. Here we present the results of a study to discover the effect of menopausal status and HRT use on breast dose. Women attending routine screening completed questionnaires which included questions regarding menopausal status and HRT use. Details of the radiographic technique factors were recorded, from which the mean glandular dose (MGD) per film for each woman was calculated. MGD values were analysed with regard to the woman's menopausal status and HRT use. The data from 516 women were analysed. Among the women who had never used HRT, women who had not undergone the menopause had a mean MGD of 2.94 mGy per film, whereas post-menopausal women had a lower mean MGD of 2.52 mGy per film: a difference which was found to be highly significant (p = 0.0045). Post-menopausal women who had never used HRT and those who had previously used HRT, but had ceased using it, had identical mean MGDs (2.54 mGy per film), whereas current HRT users had a significantly greater mean MGD (2.89 mGy per film, p = 0.003). Women currently using HRT receive a statistically significantly larger radiation dose from routine breast screening than other women. However, this effect is small and only occurs during the period of HRT use. Women who have ceased using HRT show no difference in MGD compared with women who have never taken HRT. |
| Databáze: | OpenAIRE |
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