YM-202204, a New Antifungal Antibiotic Produced by Marine Fungus Phoma sp

Autor:	Kazuma Kamigiri, Masakazu Yamaoka, Masato Watanabe, Koji Nagai, Hisao Matsumoto, Hitoshi Shimoi, Kenichi Suzuki, Yasuhiro Kawano
Rok vydání:	2002
Předmět:	Antifungal Agents Magnetic Resonance Spectroscopy Glycosylphosphatidylinositols medicine.drug_class Antibiotics Drug Evaluation Preclinical Fungus Microbial Sensitivity Tests Saccharomyces cerevisiae Alkenes Aspergillus fumigatus Microbiology Inhibitory Concentration 50 Lactones Ascomycota Candida albicans Drug Discovery medicine Humans Pharmacology Cryptococcus neoformans Molecular Structure biology Antifungal antibiotic Chemistry General Medicine Fungi imperfecti Classification biology.organism_classification Yeast carbohydrates (lipids) Fermentation Phoma lipids (amino acids peptides and proteins) Water Microbiology HeLa Cells
Zdroj:	The Journal of Antibiotics. 55:1036-1041
ISSN:	1881-1469 0021-8820
DOI:	10.7164/antibiotics.55.1036
Popis:	A new antifungal antibiotic, YM-202204 (1), was found in the culture broth of marine fungus Phoma sp. Q60596. The structure of 1 was determined by several spectroscopic experiments as a new lactone compound. This antibiotic exhibited potent antifungal activities against Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, and also inhibited glycosyl-phosphatidyl-inositol (GPI)-anchoring in yeast cells.
Databáze:	OpenAIRE
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