CHROMOSOMES OF HUMAN THYROID TUMORS
| Autor: | E.L. Socolow, Eric Engel, Linda Mantooth, J.B. Stanbury |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Adenoma
medicine.medical_specialty Pathology Pseudodiploid Biology Adenocarcinoma Chromosomes Tissue Culture Techniques Tissue culture Internal medicine Neoplasms Genetics medicine Humans Radiation Genetics Thyroid Neoplasms Molecular Biology Genetics (clinical) Chromosome Aberrations B chromosome Thyroid Cancer Chromosome medicine.disease Endocrinology medicine.anatomical_structure |
| Zdroj: | Cytogenetics. 3 |
| ISSN: | 0011-4537 |
| Popis: | Cytogenetic studies of one malignant and five benign human thyroid tumors grown in tissue culture are presented. In a follicular adenocarcinoma, a hyperdiploid stemline with supernumerary chromosomes in all groups was found. Abnormal chromosomes were not seen. In four of the adenomas studied, most of the cells had a normal chromosome complement. A history of prior x-irradiation to the face and neck was obtained from a fifty-four-year-old patient with a histologically benign microfollicular adenoma. Almost all of the cells had 46 chromosomes, but only a few had a normal karyo-type. The majority had a pseudodiploid chromosome complement due to either loss or acquisition of members of various groups, or the presence of abnormal chromosomes of varying size and configuration. |
| Databáze: | OpenAIRE |
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