Microscopic features of small bowel mucosa of patients with Crohn’s disease
| Autor: | Zhihua Ran, Yun Cui, Xiaoyu Chen, Jie Xu, Qi Miao, Xiao-qing Wang, Yanshen Peng, Shi-yuan Lu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Enteroscopy
Crohn’s disease Adult Male medicine.medical_specialty Pathology Adolescent Biopsy Lymphangitis Histopathology Lymphangiectasia 03 medical and health sciences 0302 clinical medicine Crohn Disease Internal medicine Intestine Small medicine Humans lcsh:RC799-869 Intestinal Mucosa Aged Double-Balloon Enteroscopy Crohn's disease Granuloma business.industry Gastroenterology General Medicine Hepatology Middle Aged medicine.disease digestive system diseases Granulomatous lymphangitis 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology lcsh:Diseases of the digestive system. Gastroenterology Female business Epithelioid cell Research Article |
| Zdroj: | BMC Gastroenterology BMC Gastroenterology, Vol 19, Iss 1, Pp 1-8 (2019) |
| DOI: | 10.21203/rs.2.11485/v3 |
| Popis: | Background Double-balloon enteroscopy enables performing numerous small bowel biopsies for pathologic analysis. However, most histopathological characteristics of Crohn’s disease are non-specific characteristics. We aimed to explore the small bowel mucosal histopathologic characters of Crohn’s disease and identify some disease-specific changes. Methods We included 253 patients without tumors and grouped them into Crohn’s disease, suspected Crohn’s disease, and non-Crohn’s disease groups. These patients underwent double-balloon endoscopy examination and small bowel biopsy at Renji Hospital, Shanghai. All histopathological sections were reviewed, and > 20 histopathological parameters were assessed. Immunohistochemistry was conducted when necessary. Results There were different forms of granulomatous lymphangitis on the small bowel mucosa in Crohn’s disease. They showed as various macrophages or epithelioid cells in the lumina of lymphatics or in the center of the villi with or without evident obstruction. These features were only observed in Crohn’s disease patients. Furthermore, they were correlated with granuloma and lymphangiectasia. Additionally, 15 other features showed significant differences among the three groups, and Crohn’s disease patients showed an average of almost seven histopathological characteristics. Conclusions We described the detailed morphologies of granulomatous lymphangitis on the small bowel mucosa and recommend it as a useful histopathological feature for the diagnosis of Crohn’s disease. In terms of specificity and sensitivity, it was superior to non-caseating epithelioid granuloma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|