Anxiety-like behavior as an early endophenotype in the TgF344-AD rat model of Alzheimer's disease
| Autor: | Benjamin J. Clark, Laura E. Berkowitz, Nathan S. Pentkowski, Emma Drake, Shannon M. Thompson, Carlos R. Olguin |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Aging Endophenotypes Amyloid beta Spatial Behavior Morris water navigation task Anxiety Article Transgenic Model Pathogenesis 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Memory Amyloid precursor protein medicine Animals Dementia Maze Learning biology General Neuroscience medicine.disease Disease Models Animal 030104 developmental biology Endophenotype biology.protein Female Neurology (clinical) Rats Transgenic Geriatrics and Gerontology Alzheimer's disease Psychology Neuroscience 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Neurobiol Aging |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2017.09.024 |
| Popis: | Alzheimer's disease (AD) is characterized by progressive cognitive decline and the presence of aggregates of amyloid beta (plaques) and hyperphosphorylated tau (tangles). Early diagnosis through neuropsychological testing is difficult due to comorbidity of symptoms between AD and other types of dementia. As a result, there is a need to identify the range of behavioral phenotypes expressed in AD. In the present study, we utilized a transgenic rat (TgF344-AD) model that bears the mutated amyloid precursor protein as well as presenilin-1 genes, resulting in progressive plaque and tangle pathogenesis throughout the cortex. We tested young adult male and female TgF344-AD rats in a spatial memory task in the Morris water maze and for anxiety-like behavior in the elevated plus-maze. Results indicated that regardless of sex, TgF344-AD rats exhibited increased anxiety-like behavior in the elevated plus-maze, which occurred without significant deficits in the spatial memory. Together, these results indicate that enhanced anxiety-like behavior represents an early-stage behavioral marker in the TgF344-AD rat model. |
| Databáze: | OpenAIRE |
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