Pattern of and survival following loco-regional and distant recurrence in patients with HPV+ and HPV- oropharyngeal squamous cell carcinoma: A population-based study
Autor: | Jeppe Friborg, Christian Grønhøj, Elo Andersen, David Hebbelstrup Jensen, Kathrine Kronberg Jakobsen, Jacob H. Rasmussen, Christian von Buchwald |
---|---|
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Oncology Adult Male Cancer Research medicine.medical_specialty Alphapapillomavirus 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans In patient Risk factor Neoplasm Metastasis Aged Neoplasm Staging Lung Performance status Proportional hazards model business.industry Incidence (epidemiology) Distant recurrence Middle Aged Prognosis Oropharyngeal Neoplasms 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cohort Carcinoma Squamous Cell Female Oral Surgery Neoplasm Recurrence Local business |
Zdroj: | Oral oncology. 83 |
ISSN: | 1879-0593 |
Popis: | Objectives The incidence of human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (OPSCC) is increasing. Currently, data is sparse on the pattern and timing of recurrence. This long-term study concerning both HPV- and p16-status aimed to report predictive factors, pattern, timing of loco-regional recurrence (LRR) and distant recurrence (DR), and survival following recurrence in patients diagnosed with OPSCC. Material and methods We included patients diagnosed with OPSCC from 2000 to 2014 in Eastern Denmark, who were treated with curative intent. Tumors were defined as HPV-positive when they were both HPV-DNA and p16-positive. Time-to-failure and -death were estimated by the Kaplan-Meier method. Cox proportional hazards models were used to evaluate predictors of failure. Results The cohort consisted of 1244 consecutive patients with OPSCC of which 288 patients (23%) experienced recurrence. Of these patients, the majority (n = 197/1244; 16%) experienced LRR and the remaining (n = 91/1244; 7%) DR. Significantly more HPV-negative patients experienced recurrence (n = 170/486; 35%) compared to HPV-positive patient (n = 112/726; 15%). DR occurred for both groups predominantly to the lung (n = 63/91; 69.2%) followed by the liver and bone. Factors influencing risk of LRR included gender, T-classification, and HPV-status. The same variables influenced risk of DR in addition to the UICC-8 classification, N-classification, pack years of smoking, and performance status. HPV-status was the strongest risk factor for LRR and DR. Conclusion LRR and DR occur significantly less often in HPV-positive patients compared with HPV-negative patients. HPV-status is an independent and strong predictor of recurrence. DR most commonly occurs to the lungs, irrespective of HPV-status. |
Databáze: | OpenAIRE |
Externí odkaz: |