Type 2 Diabetes: An Atherothrombotic Syndrome
| Autor: | E J Dunn, P J Grant |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Blood Platelets
medicine.medical_specialty medicine.medical_treatment Population Type 2 diabetes Fibrinogen Biochemistry Insulin resistance Internal medicine Diabetes mellitus Plasminogen Activator Inhibitor 1 von Willebrand Factor Fibrinolysis medicine Animals Humans Endothelial dysfunction education Blood Coagulation Molecular Biology Clotting factor Hemostasis education.field_of_study Factor VIII Factor XIII business.industry Thrombosis Syndrome General Medicine Factor VII medicine.disease Endocrinology Diabetes Mellitus Type 2 Tissue Plasminogen Activator Factor XII Molecular Medicine Endothelium Vascular Insulin Resistance business medicine.drug |
| Zdroj: | Current Molecular Medicine. 5:323-332 |
| ISSN: | 1566-5240 |
| DOI: | 10.2174/1566524053766059 |
| Popis: | Insulin resistance is found in around 80-90% of subjects with older onset (type 2) diabetes and in approximately 25% of the general population. Insulin resistance prior to the development of frank type 2 diabetes and type 2 diabetes itself is associated with a significant increase in the risk of atherothrombotic disease, which is due in part to a disruption in the balance of factors regulating coagulation and fibrinolysis. Both insulin resistance and type 2 diabetes are associated with the development of endothelial dysfunction, and enhanced platelet aggregation and activation. Whilst the plasma levels of many clotting factors including fibrinogen, FVII, FVIII, FXII, FXIII b-subunit are elevated, the fibrinolytic system is relatively inhibited as a consequence of an increase in plasminogen activator inhibitor type-1 (PAI-1) levels. These changes favour the development of a hypercoagulable pro-thrombotic state, which may in turn enhance cardiovascular risk by increasing the likelihood of developing an occlusive thrombus within a coronary/cerebral artery, and/or contributing to the development of atherosclerotic lesions. This article reviews the current published evidence of the pro-thrombotic changes that occur in association with type 2 diabetes and insulin resistance, and the putative underlying mechanisms which lead to these changes. |
| Databáze: | OpenAIRE |
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