Risk factors and evolution of Ventilator-associated pneumonia by Staphylococcus aureus sensitive or resistant to oxacillin in patients at the intensive care unit of a Brazilian University Hospital
| Autor: | Paulo Pinto Gontijo Filho, Renata L. Cardoso, Michel Rodrigues Moreira, Alair Benedito Almeida |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Microbiology (medical)
Adult Male Pediatrics medicine.medical_specialty Staphylococcus aureus medicine.drug_class medicine.medical_treatment Penicillin Resistance Antibiotics lcsh:QR1-502 medicine.disease_cause lcsh:Microbiology law.invention lcsh:Infectious and parasitic diseases Hospitals University law Risk Factors Pneumonia Staphylococcal medicine Humans Ventilator-associated pneumonia In patient lcsh:RC109-216 Hospital infection Oxacillin Mechanical ventilation business.industry Case-control study Pneumonia Ventilator-Associated Middle Aged medicine.disease Antimicrobial bacterial infections and mycoses Intensive care unit Anti-Bacterial Agents respiratory tract diseases Intensive Care Units Infectious Diseases Case-Control Studies Resistant microorganisms Female business Brazil |
| Zdroj: | Brazilian Journal of Infectious Diseases, Volume: 12, Issue: 6, Pages: 499-503, Published: DEC 2008 Brazilian Journal of Infectious Diseases, Vol 12, Iss 6, Pp 499-503 Brazilian Journal of Infectious Diseases v.12 n.6 2008 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
| Popis: | This study investigated the participation and risk factors of VAP by resistant (ORSA) or sensitive (OSSA) S. aureus to oxacillin and evaluated the implications of adequate or inadequate empirical antimicrobial therapeutics in its evolution in patients interned in a mixing ICU of adults. A patient control-case study with PAVs by ORSA and OSSA was carried out from May 2005 to April 2007 involving 993 patients. VAP was defined based on clinical, radiological, and microbiological (> 106 CFU/mL count in the tracheal aspirate) criteria. Four hundred and seventy four (47.7%) patients were submitted to mechanical ventilation with 141 (29.7%) VAPs, with S. aureus as the most frequent agent (41.2%). The phenotype ORSA accounted for 47.5% and OSSA for 52.5%, predominant in late-onset VAPs with frequencies of 93.1% and 68.7%, respectively. Age > 60, use of corticoid and previous antibiotic therapy were related (p0.05) in the group with VAP by ORSA (37.9%). S. aureus was the main agent of VAPs, around half by ORSA, associated with age, late-onset VAP development and previous use of antibiotics and corticoids, but with no significant difference in mortality compared with VAP by OSSA. |
| Databáze: | OpenAIRE |
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