Influence of Sulfoxide Group Placement on Polypeptide Conformational Stability
| Autor: | Timothy J. Deming, Eric G. Gharakhanian, Ehab Bahrun |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Aqueous solution
Protein Conformation Stereochemistry Sulfoxide General Chemistry 010402 general chemistry 01 natural sciences Biochemistry Catalysis 0104 chemical sciences Solvent chemistry.chemical_compound Homologous series Colloid and Surface Chemistry chemistry Chain (algebraic topology) Group (periodic table) Safrole Chemical Sciences Generic health relevance Conformational stability Peptides |
| Zdroj: | Journal of the American Chemical Society, vol 141, iss 37 |
| ISSN: | 1520-5126 0002-7863 |
| Popis: | The synthesis of a homologous series containing five new nonionic sulfoxide containing polypeptides was described. Sulfoxide groups bestowed water solubility for all homologues, which allowed their use as a model for study of helix-coil transitions in water while avoiding contributions from charged groups or phase separation. Polypeptides were found to adopt chain conformations in water that were dependent on distance of sulfoxides from chain backbones, overall side-chain lengths, and solvent. These results allow preparation of polypeptide segments with different chain conformations without changing chemical functionality for potential use in structural studies and functional applications. |
| Databáze: | OpenAIRE |
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