Spiramycin concentrations in female pelvic tissues, determined by HPLC: a preliminary report
| Autor: | M. A. Glasier, D. Vachon, M. W. Khalil, H. H. Allen |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Microbiology (medical) medicine.medical_specialty Tissue concentrations medicine.drug_class Antibiotics Urology Leucomycins High-performance liquid chromatography Pelvis Preliminary report Oral administration medicine Humans Tissue Distribution Pharmacology (medical) Chromatography High Pressure Liquid Aged Pharmacology business.industry Spiramycin Middle Aged biochemical phenomena metabolism and nutrition Gynaecological surgery Infectious Diseases medicine.anatomical_structure Anesthesia Female business Fallopian tube medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 22:111-116 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/22.supplement_b.111 |
| Popis: | An automated high performance liquid chromatographic method with remote controlled column switching was used to measure the concentration of spiramycin in pelvic tissues and plasma after oral administration of the antibiotic. Three oral doses of 2 g spiramycin were given to patients scheduled for elective gynaecological surgery over the 14 h before 6 a.m. on the day of surgery. Spiramycin concentrations in serum ranged from 7.4 to 12.5 mg/l between 3 h 20 min and 9 h 20 min after the last dose of spiramycin. Spiramycin pelvic tissue concentrations were determined in five of the eleven females and ranged from 4.4 to 33.3 mg/kg. The highest concentrations were observed in the Fallopian tube. These preliminary results suggest that spiramycin has good diffusion into female pelvic tissues. |
| Databáze: | OpenAIRE |
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