Value of transrectal ultrasonography for tumor node metastasis restaging in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy
| Autor: | Chengtao Wang, Jian-Hua Zhou, Rong Huang, Kaiyun You, Yuanhong Gao, Bixiu Wen, Hong-Bo Shan, Mengzhong Liu, Xiao-Qing Pei, Hai-hua Peng |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Oncology
neo-chemoradiotherapy (neo-CRT) medicine.medical_specialty medicine.diagnostic_test Colorectal cancer business.industry medicine.medical_treatment Ultrasound Gastroenterology Locally advanced Original Articles medicine.disease urologic and male genital diseases Internal medicine medicine Transrectal ultrasonography In patient transrectal ultrasonography (TRUS) TNM restaging Radiology Rectal cancer Tumor node metastasis business Neoadjuvant therapy Neoadjuvant chemoradiotherapy |
| Zdroj: | Gastroenterology Report |
| ISSN: | 2052-0034 |
| Popis: | Objective: To explore the value of transrectal ultrasonography (TRUS) for tumor node metastasis (TNM) restaging for patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy (neo-CRT). Methods: One hundred and forty-nine patients with locally advanced rectal cancer (cT3-4 or cN+) who underwent TRUS after neo-CRT were retrospectively reviewed. TRUS restaging was compared with the results of post-operative pathological TNM findings. Results: After neo-CRT, the accuracy of TRUS for diagnosing T-staging was 30.9%, with 60.4% (90/149) of cases overestimated. The sensitivity of TRUS for T-staging (T0 vs T1 vs T2 vs T3 vs T4) were 16.3%, 0%, 12.5%, 42.6% and 75.0%, respectively. The accuracy of TRUS for diagnosing N-staging after neo-CRT was 81.2%, with the sensitivities of N0 and N+ were 93.3% and 31.0%, respectively. After neo-CRT, 27.5% (41/149) of patients achieved pathologically complete response (pCR). The sensitivity, specificity, positive predictive value and negative predictive values of TRUS for pCR were 17.1%, 99.1%, 87.5% and 75.9%, respectively. Conclusions: TRUS can be applied for restaging T4 and N0, and has potential for screening out patients with pCR in those with locally advanced rectal cancer after neo-CRT, although some stages are overestimated for T-staging and its sensitivity for predicting pCR is low. |
| Databáze: | OpenAIRE |
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