Development of a Computational Fluid Dynamics (CFD)-Model of the Arterial Epicardial Vasculature
| Autor: | Martens, Johannes, Panzer, Sabine, van den Wijngaard, Jeroen P. H. M., Siebes, Maria, Schreiber, Laura M., Coudière, Yves, Zemzemi, Nejib, Ozenne, Valéry, Vigmond, Edward |
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| Přispěvatelé: | Biomedical Engineering and Physics, Translational Physiology, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Physics
Systematic error business.industry Quantitative Biology::Tissues and Organs Physics::Medical Physics 0206 medical engineering In-silico modeling 02 engineering and technology Blood flow 030204 cardiovascular system & hematology Computational fluid dynamics 020601 biomedical engineering Imaging data Cardiac perfusion Coronary arteries 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance medicine.anatomical_structure Epicardial blood flow medicine Development (differential geometry) business |
| Zdroj: | Functional Imaging and Modeling of the Heart ISBN: 9783030219482 FIMH Functional Imaging and Modeling of the Heart-10th International Conference, FIMH 2019, Proceedings, 11504 LNCS, 219-229 |
| ISSN: | 0302-9743 |
| Popis: | Motivation of the project is the analysis of systematic errors in contrast-enhanced cardiac perfusion imaging by CFD simulations of contrast agent transport in the arterial epicardial vasculature. This requires the realistic modeling of volume blood flow (VBF) in the coronary arteries to provide a physiologically relevant computational framework for the transport simulations. For this purpose, 3D-models of the left and right coronary trees are extracted from high-resolution cardiovascular cryomicrotome imaging data and meshed with computational grids. A dedicated model integrating characteristics of coronary blood flow is used to generate boundary conditions (BCs). Subsequently, VBF is analyzed in left and right ventricular myocardial regions (\(\mathrm{VBF}_\mathrm{m}\)) and in dependence of the vessel sizes (\(\mathrm{VBF}_\mathrm{v}\)). Regarding the distribution of \(\mathrm{VBF}_\mathrm{m}\) in the myocardial segments, good agreement with literature values is found. Partial compliance of the findings of the \(\mathrm{VBF}_\mathrm{v}\)-analysis with results from other groups is promising, however, indicates room for improvement. |
| Databáze: | OpenAIRE |
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