Calcineurin regulation of cytoskeleton organization: a new paradigm to analyse the effects of calcineurin inhibitors on the kidney
| Autor: | Marie Essig, Virginie Descazeaud, Elodie Mestre, Pierre Marquet |
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| Přispěvatelé: | Marquet, Pierre, Pharmacologie des Immunosuppresseurs et de la Transplantation (PIST), Université de Limoges (UNILIM)-CHU Limoges-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Pharmacologie, toxicologie et pharmacovigilance [CHU Limoges], CHU Limoges, Service de Néphrologie, Dialyse, Transplantations [CHU Limoges] |
| Rok vydání: | 2012 |
| Předmět: |
MESH: Signal Transduction
kidney Cytoskeleton organization Calcineurin Inhibitors MESH: Neurons MESH: Myocytes Cardiac MESH: NFATC Transcription Factors Cardiomegaly Review 030204 cardiovascular system & hematology Biology 03 medical and health sciences 0302 clinical medicine MESH: Cytoskeleton Humans Myocytes Cardiac Cytoskeleton 030304 developmental biology Neurons 0303 health sciences MESH: Humans NFATC Transcription Factors nephrotoxicity Calcineurin cytoskeleton Heart NFAT MESH: Kidney Cell Biology [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences Cofilin Cell biology [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences MESH: Heart Molecular Medicine Synaptopodin MESH: Calcineurin MESH: Cardiomegaly Signal transduction Signal Transduction |
| Zdroj: | Journal of Cellular and Molecular Medicine Journal of Cellular and Molecular Medicine, Wiley Open Access, 2012, 16 (2), pp.218-27. ⟨10.1111/j.1582-4934.2011.01398.x⟩ |
| ISSN: | 1582-1838 1582-4934 |
| Popis: | International audience; Calcineurin is a serine/threonine phosphatase originally involved in the immune response but is also known for its role as a central mediator in various non-immunological intracellular signals. The nuclear factor of activated T cell (NFAT) proteins are the most widely described substrates of calcineurin, but ongoing work has uncovered other substrates among which are the cytoskeleton organizing proteins (i.e. cofilin, synaptopodin, WAVE-1). Control over cytoskeletal proteins is of outmost interest because the phenotypic properties of cells are dependent on cytoskeleton architecture integrity, while rearrangements of the cytoskeleton are implicated in both physiological and pathological processes. Previous works investigating the role of calcineurin on the cytoskeleton have focused on neurite elongation, myocyte hypertrophic response and recently in kidney cells structure. Nuclear factor of activated T cell activation is expectedly identified in the signalling pathways for calcineurin-induced cytoskeleton organization, however new NFAT-independent pathways have also been uncovered. The aim of this review is to summarize the current knowledge on the effects of calcineurin on cytoskeletal proteins and related intracellular pathways. These newly described properties of calcineurin on cytoskeletal proteins may explain some of the beneficial or deleterious effects observed in kidney cells associated with the use of the calcineurin inhibitors, cyclosporine and tacrolimus. |
| Databáze: | OpenAIRE |
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