Prospective of Nanotechnology Application for the Treatment of HCV
Autor: | Jahangeer, Muhammad, Zawar Hussain, Azka Maryam, Areej Riasat, Ambreen, Alia, Shoukat Hussain, Mahmood, Zahed, Wasfa Batool, Mahvish Ashiq, Sumia Urainab |
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Rok vydání: | 2023 |
Předmět: | |
DOI: | 10.5281/zenodo.7585915 |
Popis: | Chronic Hepatitis C infection is a common worldwide disorder, caused by Hepatitis C Virus (HCV). Right around 180 million individuals are affected by Hepatitis C Virus infection globally and more than 50 million in South Asia. Ribavirin and interferon are used for many years for the treatment of HCV, direct acting agents, and combination therapy as well. The main problem with these therapies is that a lot of side effects are observed. A novel procedure is utilized for the treatment of HCV which is called nanotechnology. The major advantages of those technology are that there is no wastage of drugs and avoid the hydrolysis of drugs. Different kinds of the bearer are utilized as a part of the treatment of HCV like nanoparticles, bio-conjugation, micelle development and dendrites. Diverse sorts of Nano transporters are utilized that convey the medication stacked particles to target points and diminish symptoms. According to this description, the part of nanocomposite like a transporter for anti-hepatitis C virus vaccine, anti-hepatitis C virus deoxyribozymes, anti-HCV aptamers, anti-HCV phenolic compounds and their focused-on conveyance are talked about. Additionally, nanoparticles give a different strategy to antigen conveyance, which not just actuates distinctive components of the same framework yet, in addition, has great biocompatibility. {"references":["1.\tSchaefer EA, Chung RT. Anti− Hepatitis C Virus Drugs in Development. Gastroenterology. 2012 May 1;142(6):1340-50.","2.\tShepard CW, Finelli L, Alter MJ. Global epidemiology of hepatitis C virus infection. The Lancet infectious diseases. 2005 Sep 1;5(9):558-67.","3.\tBlach S, Zeuzem S, Manns M, Altraif I, Duberg AS, Muljono DH, Waked I, Alavian SM, Lee MH, Negro F, Abaalkhail F. Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study. 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