Major Stressful Life Events and Risk of Developing Lung Cancer: A Case-Control Study

Autor:	Syed H Jafri, Arash Mollaeian, Mahran Shoukier, Rahat Hussain, Syed Mojiz Hasan, Hazem Edmond El-Osta, Bindu Akkanti, Faisal Ali, Jessica T. Williams
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	0301 basic medicine Oncology medicine.medical_specialty business.industry Life events Case-control study medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens lcsh:RC254-282 smoking 03 medical and health sciences stress lung cancer 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine medicine β-blockers risk factors business Lung cancer Original Research
Zdroj:	Clinical Medicine Insights. Oncology Clinical Medicine Insights: Oncology, Vol 13 (2019)
ISSN:	1179-5549
Popis:	Background: Lung cancer is the leading cause of cancer-related mortality and is strongly linked with smoking. We sought to determine whether major stressful life events (e.g. divorce) are also a risk factor for developing lung cancers. Methods: We performed a matched case-control study. Cases (CA) were lung cancer patients diagnosed within the previous 12 months. Controls (CO) were patients without a prior history of malignancy. Data on major stressful life events were collected using the modified Holmes-Rahe stress scale. The primary endpoint was the odds of having a major stressful life event between CA and CO. A sample of 360 patients (CA = 120, CO = 240) was needed to achieve 80% power to detect an odds ratio (OR) of 2.00 versus the alternative of equal odds using χ2 = 0.05. Results: Between May 2015 and December 2016, we enrolled 301 patients (CA = 102, CO = 199), matched for median age (CA = 64.4 years, CO = 63.9 years), sex (CA-Male = 48%, CO-Male = 49.2%), and smoking status (ever smoker, CA = 84%, CO = 85%). There was no difference in lifetime stressful life event rate between CA and CO (95% vs 93.9%; P = .68). However, CA were significantly more likely to have had a stressful event within the preceding 5 years than CO (CA = 77.4% vs CO = 65.8%; P = .03, OR = 1.78). β-blocker use was significantly higher among CO (CA = 29.4%, CO = 49.7%; P = .0007, OR = 0.42), suggesting a protective effect. Conclusion: Patients with lung cancer are significantly more likely to have had a major stressful life event within the preceding 5 years. In addition, use of β-blockers may be protective against lung cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917c1b1e10cc263c6d7c79be3922c7d8 http://europepmc.org/articles/PMC6495441 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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