Comparative effects of imipramine and dothiepin on salivary rate in normal volunteers

Autor:	PK Pispati, Sheth Uk, NK Desai, Teresa Paul
Rok vydání:	1979
Předmět:	Pharmacology Dibenzothiepins Imipramine Time Factors business.industry Significant difference Placebo Normal volunteers Double-Blind Method Dothiepin Anesthesia medicine Humans Pharmacology (medical) business Salivation medicine.drug Research Article
Zdroj:	British journal of clinical pharmacology. 8(5)
ISSN:	0306-5251
Popis:	1 Imipramine induced significant reduction in salivary rate compared to placebo in a cross-over, double-blind study of twelve normal volunteers. In contrast, there was no significant difference between the reduction in salivary rate induced by dothiepin and placebo. 2 Comparison of salivary rates showed no significant difference between the drugs in the initial and cross-over treatment periods. However, pooled observations from the initial and cross-over treatment periods indicated that imipramine produced a significantly greater reduction in salivary rate than dothiepin. 3 The results suggest that dothiepin would cause far less dryness of mouth compared to imipramine. This feature might ensure greater therapeutic compliance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917ac684d2f192c57564edeedebd6f15 https://pubmed.ncbi.nlm.nih.gov/508554 Zobrazit plný text záznamu Plný text