The effect of tri-iodothyronine administration on protein synthesis in the diabetic rat
| Autor: | D. J. Millward, J. G. Brown, J. van Bueren |
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| Jazyk: | angličtina |
| Rok vydání: | 1983 |
| Předmět: |
Male
History medicine.medical_specialty Diabetic rat Muscle Proteins Biology Education Diabetes Mellitus Experimental Tri iodothyronine Inbred strain Diabetes mellitus Internal medicine medicine Protein biosynthesis Animals Triiodothyronine Muscles Thyroid RNA Rats Inbred Strains medicine.disease Computer Science Applications Rats Endocrinology medicine.anatomical_structure Liver Protein Biosynthesis Research Article |
| Popis: | In young male rats diabetes caused decreases in circulating free tri-iodothyronine and RNA concentration in liver and muscle, and in the rate of protein synthesis per unit of RNA (RNA activity) in muscle. Tri-iodothyronine treatment significantly increased RNA concentrations, but not RNA activity, in these tissues. Thus: (1) impaired thyroid status is a component of the diabetic condition; (2) tri-iodothyronine cannot stimulate the translational phase of protein synthesis in the diabetic rat. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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