The blockade of the renin-angiotensin system reverses tacrolimus related cardiovascular toxicity at the histopathological level
| Autor: | Mehmet Agirbasli, Hicran Deniz, Serhan Tuglular, Fulya Cakalagaoglu, Emel Akoglu, Betul Ogutmen, Nurdan Papila-Topal |
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| Přispěvatelé: | Agirbasli, Mehmet, Papila-Topal, Nurdan, Ogutmen, Betul, Deniz, Hicran, Cakalagaoglu, Fulya, Tuglular, Serhan, Akoglu, Emel |
| Rok vydání: | 2007 |
| Předmět: |
cardiac toxicity
EXPRESSION Male medicine.medical_specialty Medicine (General) TRANSPLANT RECIPIENT CYCLOSPORINE-A Angiotensin-Converting Enzyme Inhibitors 030204 cardiovascular system & hematology Pharmacology Cardiovascular System Tacrolimus Renin-Angiotensin System 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology R5-920 MESANGIAL CELLS Internal medicine Renin–angiotensin system Internal Medicine medicine polycyclic compounds FIBROSIS Animals Rats Wistar biology GROWTH-FACTOR-BETA organic chemicals Myocardium TGF-BETA DIABETES-MELLITUS Heart Blockade Rats Vascular endothelial growth factor Valsartan chemistry Enzyme inhibitor Quinapril FK506 NEPHROTOXICITY biology.protein cardiovascular system Immunohistochemistry medicine.drug |
| Zdroj: | Journal of the Renin-Angiotensin-Aldosterone System, Vol 8 (2007) |
| ISSN: | 1470-3203 |
| Popis: | Introduction. In this study, we investigate the toxic effects of tacrolimus (FK506) on the cardiovascular system at the histopathological level in a rat model and whether these effects can be reversed by the blockade of the renin-angiotensin system (RAS) by either an angiotensin-converting enzyme inhibitor (ACE-inhibitors) or an angiotensin receptor antagonist (ARB). Methods and results. Thirty-one Wistar rats were divided into four groups. FK506 group was treated with FK506 intraperitoneally (i.p.), FK506+ACE-inhibitors and FK506+ARB groups were treated with either quinapril or valsartan orally in addition to FK506. Control group was treated with saline i.p. Histological and immunohistochemical staining of cardiovascular tissue in the FK506 group showed increased vacuolar degeneration (11.2 vs. 5.8, p=0.008), arterial hyalinosis (10.7 vs. 6. G 3, p=0.036), transforming growth factor-beta (TGF-β) (12.2 vs. 4.8, p=0.001) and vascular endothelial growth factor expression (VEGF) (10.7 vs. 6.3, p=0.036), elastic van Gieson (11.5 vs. 5.5, p=0.004), and periodic acid O Schiff stain scores (12.5 vs. 4.5, p Conclusion. Blockade of RAS could reverse the histopathological signs of FK506 induced cardiac toxicity in a rat model. |
| Databáze: | OpenAIRE |
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