Recent advances on visual cycle protein research and progress on clinical translation
| Autor: | Xin Yee Ooi, Anjalee Choudhury, Jeff G. Grigsby, Brandi Obregon, Francisco Xavier Elisarraras, Andrew Tsin, Rujman Khan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
RP
genetic structures business.industry LCA Genetic enhancement Visual Cycle Translation (biology) RPE 65 Gene Therapy Disease Diabetic retinopathy Leber congenital amaurosis medicine.disease Article eye diseases Clinical trial DR IRBP Retinitis pigmentosa medicine DES1 business Neuroscience STGD Visual phototransduction |
| Zdroj: | Archives of clinical and experimental ophthalmology |
| ISSN: | 2692-4331 |
| Popis: | Since the publication of our previous paper, Visual cycle proteins: Structure, function, and roles in human retinal disease (Tsin, et.al, JBC 293:13016, 2018) there has been significant progress on multiple topics discussed in this paper. In the present communication, we further explore research advances on two visual cycle proteins: DES1 and IRBP. In addition, we emphasize the progress of clinical translation of other visual cycle protein research, including the breakthrough of FDA-approved gene therapy for Leber’s congenital amaurosis, and additional gene therapies at different stages of clinical trials for various retinal diseases such as retinitis pigmentosa, diabetic retinopathy, and Stargardt’s disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|