Thoughts on cartilage tissue engineering: A 21st century perspective
| Autor: | Theofanis Stampoultzis, Peyman Karami, Dominique P. Pioletti |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cartilage
Articular 0301 basic medicine Engineering General Biochemistry Genetics and Molecular Biology Cartilage tissue engineering Mechanobiology 03 medical and health sciences Bioreactors 0302 clinical medicine Milestone (project management) medicine Animals Humans Tissue Engineering business.industry Hyaline cartilage Clinical translation Cartilage Perspective (graphical) General Medicine Bench to bedside 3. Good health 030104 developmental biology medicine.anatomical_structure Cartilage regeneration 030220 oncology & carcinogenesis Quality of Life Engineering ethics business Biofabrication |
| Zdroj: | Current Research in Translational Medicine. 69:103299 |
| ISSN: | 2452-3186 |
| DOI: | 10.1016/j.retram.2021.103299 |
| Popis: | In mature individuals, hyaline cartilage demonstrates a poor intrinsic capacity for repair, thus even minor defects could result in progressive degeneration, impeding quality of life. Although numerous attempts have been made over the past years for the advancement of effective treatments, significant challenges still remain regarding the translation of in vitro cartilage engineering strategies from bench to bedside. This paper reviews the latest concepts on engineering cartilage tissue in view of biomaterial scaffolds, tissue biofabrication, mechanobiology, as well as preclinical studies in different animal models. The current work is not meant to provide a methodical review, rather a perspective of where the field is currently focusing and what are the requirements for bridging the gap between laboratory-based research and clinical applications, in light of the current state-of-the-art literature. While remarkable progress has been accomplished over the last 20 years, the current sophisticated strategies have reached their limit to further enhance healthcare outcomes. Considering a clinical aspect together with expertise in mechanobiology, biomaterial science and biofabrication methods, will aid to deal with the current challenges and will present a milestone for the furtherance of functional cartilage engineering. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect