Carmustine-impregnated wafers and their impact in the management of high-grade glioma
| Autor: | Renato V La Rocca, Arash Rezazadeh |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Oncology
medicine.medical_specialty English language Internal medicine medicine Humans Pharmacology (medical) Antineoplastic Agents Alkylating High-Grade Glioma Pharmacology Clinical Trials as Topic Drug Carriers Carmustine Brain Neoplasms business.industry Therapeutic effect Glioma General Medicine medicine.disease Tumor site Surgery Drug concentration Expert opinion business Glioblastoma medicine.drug |
| Zdroj: | Expert Opinion on Pharmacotherapy. 12:1325-1332 |
| ISSN: | 1744-7666 1465-6566 |
| DOI: | 10.1517/14656566.2011.580737 |
| Popis: | Introduction: Carmustine-impregnated biodegradable wafers provide a locoregional adjunct to the treatment of patients with high-grade glial neoplasms. Their impact is that of delivering a chemotherapeutic agent directly to the tumor site at the time of neurosurgical intervention with a resulting increased local drug concentration and an ongoing therapeutic effect lasting several days to weeks. Areas covered: This manuscript reviews the preclinical and clinical studies that established carmustine-impregnated wafers as a locoregional therapy in the treatment of de novo as well as recurrent high-grade gliomas and compares it with other locoregional modalities currently under development. A pertinent English language literature search dating back to 1990 was undertaken. Expert opinion: Carmustine-impregnated wafers represent but one component of a multimodality armamentarium for the treatment of high-grade gliomas. The development of biodegradable compounds capable of incorporating additional therapeutic agen... |
| Databáze: | OpenAIRE |
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