Multimodal imaging of bilateral ischemic retinal vasculopathy associated with Berger’s IgA nephropathy: case report
| Autor: | Francesca Amoroso, Olivia Zambrowski, Khaled El Matri, Eric H Souied, Alexandra Miere |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
genetic structures Posterior pole 030232 urology & nephrology Fundus (eye) Vascular occlusion Nephropathy Retinal vasculopathy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ischemia Ophthalmology Multimodal imaging Case report medicine Humans Fluorescein Angiography Telangiectasia Retina medicine.diagnostic_test business.industry Retinal Vessels Glomerulonephritis IGA Retinal General Medicine Middle Aged RE1-994 Fluorescein angiography medicine.disease OCT-Angiography eye diseases medicine.anatomical_structure chemistry 030221 ophthalmology & optometry Berger IgA nephropathy Female sense organs medicine.symptom business Tomography Optical Coherence |
| Zdroj: | BMC Ophthalmology, Vol 21, Iss 1, Pp 1-8 (2021) BMC Ophthalmology |
| ISSN: | 1471-2415 |
| Popis: | Background Berger’s IgA nephropathy (IgAN) is the most common primary glomerulonephritis. However, some rare cases of retinal manifestations have been described, with only two cases of retinal vasculopathy reported in the literature. Here we report an uncommon case of bilateral ischemic retinal vasculopathy associated with Berger IgAN, evaluated with complete multimodal imaging including ultra-wide field (UWF) imaging and swept source optical coherence tomography angiography (SS-OCTA). Case presentation A 51-year-old woman with a history of Berger’s IgA nephropathy complained of visual impairment in both eyes. Fundus examination showed bilateral peripapillary arterial attenuation and perivascular sheathing, associated to perifoveal telangiectatic lesions. There was a central scotoma in the perimetry of the right eye and peripheral visual field defect in the left eye. Full-field electroretinogram revealed significantly reduced oscillatory potentials. Spectral domain optical coherence tomography showed multiple focal areas of thinning of the inner retina, indicating long-lasting vascular occlusion lesions. UWF fluorescein angiography showed the presence of bilateral vasculitis, diffuse capillary leakage, macular ischemia and telangiectasia. SS-OCTA better highlighted the macular ischemia and vascular anomalies layer-by-layer. Conclusions Retinal vasculopathy is a very rare condition observed in IgA nephropathy. To our knowledge, this is the first report of complete multimodal functional and structural imaging. UWF imaging was very useful for accurate and comprehensive disease assessment, and OCTA was able to assess posterior pole vascular lesions. |
| Databáze: | OpenAIRE |
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