Sexually dimorphic changes in the endocrine pancreas and skeletal muscle in young adulthood following intra-amniotic IGF-I treatment of growth-restricted fetal sheep
| Autor: | Ana-Mishel Spiroski, Emma J Buckels, Mark H. Oliver, Frank H. Bloomfield, Anne L. Jaquiery, Jane E. Harding |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Physiology Endocrinology Diabetes and Metabolism Islets of Langerhans Pregnancy Physiology (medical) Internal medicine Insulin-Secreting Cells Endocrine system Medicine Animals Insulin Young adult Insulin-Like Growth Factor I Muscle Skeletal Fetus Fetal Therapies Sex Characteristics Fetal Growth Retardation Sheep biology business.industry Skeletal muscle Amniotic Fluid Sexual dimorphism Insulin receptor Endocrinology medicine.anatomical_structure Intra-Amniotic biology.protein Female business Pancreas |
| Zdroj: | American journal of physiology. Endocrinology and metabolism. 321(4) |
| ISSN: | 1522-1555 |
| Popis: | Fetal growth restriction (FGR) is associated with decreased insulin secretory capacity and decreased insulin sensitivity in muscle in adulthood. We investigated whether intra-amniotic IGF-I treatment in late gestation mitigated the adverse effects of FGR on the endocrine pancreas and skeletal muscle at 18 mo of age. Singleton-bearing ewes underwent uterine artery embolization between 103 and 107 days of gestational age, followed by 5 once-weekly intra-amniotic injections of 360-µg IGF-I (FGRI) or saline (FGRS) and were compared with an unmanipulated control group (CON). We measured offspring pancreatic endocrine cell mass and pancreatic and skeletal muscle mRNA expression at 18 mo of age ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|