Differential Initiation of Translation of a Single Estrogen Receptor mRNA Could Explain Some Estradiol Resistance Cases
| Autor: | P. Barraille, Jean-Charles Faye, H. Prats, F. Delassus, Christine Toulas, Francis Bayard |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Estradiol Testicular receptor 4 Endocrinology Diabetes and Metabolism medicine.medical_treatment Liver receptor homolog-1 Drug Resistance Estrogen receptor Biology Endocrine System Diseases Cell Line Steroid hormone Estrogen-related receptor alpha Endocrinology Receptors Estrogen Protein Biosynthesis Internal medicine medicine Animals Humans Estrogen-related receptor gamma RNA Messenger Estrogen receptor alpha Estrogen receptor beta |
| Zdroj: | ResearcherID |
| ISSN: | 1423-0046 0301-0163 |
| DOI: | 10.1159/000182493 |
| Popis: | Cell response to steroid stimulation is generally acknowledged to be mediated by an intracellular protein known as a receptor. Response intensity is related to the affinity of the receptor and to the number of sites occupied by its specific ligand. Although verified in the majority of experimental and clinical studies, certain phenomena of steroid hormone resistance would seem to challenge this assertion. Application of gene molecular biology to determine the action mechanisms of steroid hormones has partially explained cell resistance in terms of genetic modifications. The work presented here shows that in certain cases, estrogen resistance could be explained by regulation of translation of the single messenger RNA coding for the receptor. |
| Databáze: | OpenAIRE |
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