Prognostic Impact of [18F]Fluorothymidine and [18F]Fluoro-D-Glucose Baseline Uptakes in Patients with Lung Cancer Treated First-Line with Erlotinib
| Autor: | Irini Papachristou, Lukas C. Heukamp, Deniz Kahraman, Markus Dietlein, Matthias Scheffler, Walburga Engel-Riedel, Ronald Boellaard, Silvia Querings, Bernd Neumaier, Jürgen Wolf, Lucia Nogova, Thomas Zander, Reinhard Büttner, Erich Stoelben, Carsten Kobe, Adriaan A. Lammertsma |
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| Přispěvatelé: | Radiology and nuclear medicine, CCA - Disease profiling |
| Rok vydání: | 2013 |
| Předmět: |
Oncology
Male Pathology Lung Neoplasms medicine.medical_treatment Cancer Treatment lcsh:Medicine Kaplan-Meier Estimate Lung and Intrathoracic Tumors Metastasis Diagnostic Radiology Carcinoma Non-Small-Cell Lung Basic Cancer Research Clinical Trials (Cancer Treatment) lcsh:Science Lung Univariate analysis Multidisciplinary medicine.diagnostic_test Cancer Risk Factors Middle Aged Prognosis Positron emission tomography Large-cell lung carcinoma Female Oncology Agents Erlotinib Radiology medicine.drug Research Article Adult medicine.medical_specialty Drugs and Devices Genetic Causes of Cancer Erlotinib Hydrochloride Fluorodeoxyglucose F18 Internal medicine medicine Adenocarcinoma of the lung Humans Lung cancer Protein Kinase Inhibitors Aged Clinical Trial Medicine business.industry lcsh:R Cancers and Neoplasms Genes erbB-1 Chemotherapy and Drug Treatment medicine.disease Dideoxynucleosides Non-Small Cell Lung Cancer Radiation therapy Log-rank test Pharmacodynamics Positron-Emission Tomography Mutation Quinazolines lcsh:Q business |
| Zdroj: | Scheffler, M, Zander, T, Nogova, L, Kobe, C, Kahraman, D, Dietlein, M, Papachristou, I, Heukamp, L, Buttner, R, Boellaard, R, Lammertsma, A A, Querings, S, Stoelben, E, Engel-Riedel, W, Neumaier, B & Wolf, J 2013, ' Prognostic Impact of [18F]Fluorothymidine and [18F]Fluoro-D-Glucose Baseline Uptakes in Patients with Lung Cancer Treated First-Line with Erlotinib ', PLoS ONE, vol. 8, no. 1, e53081 . https://doi.org/10.1371/journal.pone.0053081 PLoS ONE PLoS ONE, 8(1):e53081. Public Library of Science PLoS ONE, Vol 8, Iss 1, p e53081 (2013) Europe PubMed Central |
| ISSN: | 1932-6203 |
| Popis: | UNLABELLED 3'-deoxy-3'-[(18)F]fluoro-L-thymidine (FLT) and 2'-deoxy-2'-[(18)F]fluoro-D-glucose (FDG) are used to visualize proliferative and metabolic activity of tumors. In this study we aimed at evaluating the prognostic value of FLT and FDG uptake measured by positron emission tomography (PET) in patients with metastatic non-small cell lung cancer (NSCLC) prior to systemic therapy with erlotinib. FLT and FDG maximum standardized uptake (SUVmax) values per patient were analyzed in 40 chemotherapy naive patients with advanced NSCLC (stage IV) before treatment with erlotinib. Prior therapy median SUVmax was 6.6 for FDG and 3.0 for FLT, respectively. In univariate analysis, patients with an FDG SUVmax |
| Databáze: | OpenAIRE |
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