Examining differences between overweight women and men in 12-month weight loss study comparing healthy low-carbohydrate vs. low-fat diets
| Autor: | Marcia L. Stefanick, Lucia Aronica, Joseph Rigdon, Lisa C. Offringa, Christopher D. Gardner |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Medicine (miscellaneous) 030209 endocrinology & metabolism Overweight Affect (psychology) Article Diet Carbohydrate-Restricted Young Adult 03 medical and health sciences 0302 clinical medicine Weight loss Internal medicine Secondary analysis Weight Loss medicine Humans Obesity Low carbohydrate Diet Fat-Restricted Nutrition 030109 nutrition & dietetics Nutrition and Dietetics business.industry Confounding Middle Aged Low fat diet Treatment Outcome Randomized controlled trials Lean body mass Patient Compliance Female medicine.symptom business |
| Zdroj: | International Journal of Obesity (2005) |
| ISSN: | 1476-5497 0307-0565 |
| DOI: | 10.1038/s41366-020-00708-y |
| Popis: | Background/objectives Biological sex factors and sociocultural gender norms affect the physiology and behavior of weight loss. However, most diet intervention studies do not report outcomes by sex, thereby impeding reproducibility. The objectives of this study were to compare 12-month changes in body weight and composition in groups defined by diet and sex, and adherence to a healthy low carbohydrate (HLC) vs. healthy low fat (HLF) diet. Participants/methods This was a secondary analysis of the DIETFITS trial, in which 609 overweight/obese nondiabetic participants (age, 18–50 years) were randomized to a 12-month HLC (n = 304) or HLF (n = 305) diet. Our first aim concerned comparisons in 12-month changes in weight, fat mass, and lean mass by group with appropriate adjustment for potential confounders. The second aim was to assess whether or not adherence differed by diet-sex group (HLC women n = 179, HLC men n = 125, HLF women n = 167, HLF men n = 138). Results 12-month changes in weight (p P p = 0.02). Weight loss estimates within group remained similar after adjusting for adherence, suggesting adherence was not a mediator. Conclusions By reporting outcomes by sex significant weight loss differences were identified between HLC and HLF, which were not recognized in the original primary analysis. These findings highlight the need to consider sex in the design, analysis, and reporting of diet trials. |
| Databáze: | OpenAIRE |
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