Generalized Seizures Following Topical Lidocaine Administration During Circumcision
| Autor: | Yaron Finkelstein, Gideon Koren, Massoud Rezvani, Craig J Railton, Zul Verjee |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Time zero Dose-Response Relationship Drug Lidocaine business.industry Administration Topical Infant Drug overdose medicine.disease Topical lidocaine Pharmacotherapy Circumcision Male Seizures Anesthesia Pediatrics Perinatology and Child Health Humans Medicine Pharmacology (medical) Naranjo Scale Anesthetics Local Drug Overdose Causation business medicine.drug |
| Zdroj: | Pediatric Drugs. 9:125-127 |
| ISSN: | 1174-5878 |
| DOI: | 10.2165/00148581-200709020-00006 |
| Popis: | We report a case of neonatal seizures after lidocaine administration for circumcision. A 3-month-old male infant received an overdose as evidenced by toxic lidocaine levels and developed generalized seizures shortly after. Back extrapolation of the serum lidocaine concentration to time zero was used to determine the administered dose. The Naranjo scale was used to determine causation; probable causation was defined. Particular care must be taken to administer an appropriate dose of local anesthetics in infants to avoid life-threatening seizures. |
| Databáze: | OpenAIRE |
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