Randomized trial of preoperative administration of oral pregabalin for postoperative analgesia in patients scheduled for radiofrequency ablation of focal lesions in the liver
| Autor: | Sherief Abd-Elsalam, Ferial El-Kalla, Fatma H. Rizk, Amr Shaaban Hanafy, Amr Ahmed Magdy Abdelfattah, Nehad Hawash |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cancer Research Carcinoma Hepatocellular Physiology Radiofrequency ablation Pregabalin Placebo law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial 030202 anesthesiology law Pain assessment Physiology (medical) Preoperative Care medicine Humans Analgesics Pain Postoperative Radiofrequency Ablation business.industry Liver Neoplasms Middle Aged medicine.disease Opioid 030220 oncology & carcinogenesis Anesthesia Hepatocellular carcinoma Female Analgesia Liver cancer business medicine.drug |
| Zdroj: | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 34(8) |
| ISSN: | 1464-5157 |
| Popis: | The aim of this study was to evaluate the effect of preoperative pregabalin on postoperative analgesia in patients undergoing radiofrequency ablation (RFA) of hepatic focal lesions (HFLs).This randomised controlled study was carried out on 70 adult patients for whom RFA was indicated to treat hepatocellular carcinoma. They were randomised into two groups: Group I: 35 patients who were given a placebo before the procedure and Group II: 35 patients who were given 150 mg of oral pregabalin one hour before the procedure. The primary outcome was the analgesic effect in the form of postoperative pain severity and the need for opioid analgesics.In the immediate postoperative period there was no significant difference between the two groups on pain assessment by the visual analogue pain scale (VAS Pain; p = 0.84). However, the medians of Group II VAS Pain were significantly (p 0.001) less than Group I 3,2,1,1,1,0 vs. 4,3,3,2,2,2, respectively when measured every four hours until 24 hours. The number of required doses of rescue analgesia and total required dose of morphine in the first 48 hours postoperatively of Group II were significantly (p 0.001) less than Group I. Side effects such as nausea and vomiting and delayed discharge were significantly less frequent in Group II when compared with Group I:20vs. 45.7%, 17.1 vs. 45.7% and 11.4 vs. 37.1%, respectively (p = 0.02, 0.01 and 0.01, respectively).Pre-emptive oral pregabalin is safe and effective for postoperative analgesia in patients scheduled for radiofrequency ablation of focal lesions in liver. |
| Databáze: | OpenAIRE |
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