Selective inhibition of the induction phase of delayed type hypersensitivity in mice by niridazole
| Autor: | C.C.A. Bernard, M.A. Vadas |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Drug
Time Factors T-Lymphocytes media_common.quotation_subject Immunology Cell Mice Inbred Strains Schistosomiasis Pathology and Forensic Medicine Niridazole Mice chemistry.chemical_compound Immune system Immunity medicine Animals Immunology and Allergy Hypersensitivity Delayed Lymph node Sensitization media_common business.industry medicine.disease Specific Pathogen-Free Organisms Mice Inbred C57BL medicine.anatomical_structure chemistry Depression Chemical Mice Inbred CBA business |
| Zdroj: | Clinical Immunology and Immunopathology. 20:313-320 |
| ISSN: | 0090-1229 |
| DOI: | 10.1016/0090-1229(81)90141-0 |
| Popis: | Niridazole, a nitrothiazole derivative, used in the treatment of schistosomiasis, inhibits cell-mediated immunity in mice. The drug depressed delayed type hypersensitivity (DTH) 3 when administered at the time of sensitization, and lymph node cells from niridazole-treated mice were found to be less efficient than cells from untreated controls in transferring DTH, or in providing helper function in a plaque-forming cell assay. In contrast, the drug was unable to prevent passive sensitization when given to the recipient of sensitized cells. These studies suggest that niridazole inhibits cell-mediated immune responses primarily by interfering with the afferent arm of T-cell sensitization. |
| Databáze: | OpenAIRE |
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