Maternal serum cytokine levels in women with hyperemesis gravidarum in the first trimester of pregnancy
| Autor: | Fatih Gücer, Mahmut Yüksel, Petek Balkanlı Kaplan, M. Ali Yüce, N. Cenk Sayin, Turgut Yardım |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Nausea medicine.medical_treatment Hyperemesis gravidarum Pregnancy Hyperemesis Gravidarum Internal medicine medicine Humans Interleukin 6 biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Obstetrics Interleukin-8 Obstetrics and Gynecology Receptors Interleukin-2 medicine.disease Pregnancy Trimester First First trimester Endocrinology Cytokine Reproductive Medicine Vomiting biology.protein Etiology Cytokines Female medicine.symptom business Interleukin-1 |
| Zdroj: | Fertility and Sterility. 79:498-502 |
| ISSN: | 0015-0282 |
| Popis: | Objective To compare serum cytokine levels in patients with hyperemesis gravidarum with levels in healthy pregnant and nonpregnant women. Design Case–control study. Setting Clinical and academic research center. Patient(s) Thirty women with hyperemesis gravidarum, 30 healthy women in the first trimester of pregnancy, and 30 healthy nonpregnant women. Main outcome measure(s) Serum levels of interleukin-1β, interleukin-2 receptor, interleukin-6, interleukin-8, and tumor necrosis factor (TNF)-α.. Result(s) Median serum levels of interleukin-2 receptor and interleukin-8 did not differ significantly among the three groups. Serum levels of interleukin-1β and interleukin-6 were significantly higher in healthy pregnant women than in healthy nonpregnant women. Median TNF-α levels were significantly higher in women with hyperemesis (25.8 pg/mL [range, 4.9–140 pg/mL]) than in healthy pregnant and nonpregnant women (10.85 pg/mL [range, 4.1–35.8 pg/mL] and 12 pg/mL [4.3–68.2 pg/mL], respectively). Conclusion(s) Levels of TNF-α were significantly higher in patients with hyperemesis gravidarum than in healthy pregnant and nonpregnant women. Thus, TNF-α may be involved in the etiology of hyperemesis gravidarum. |
| Databáze: | OpenAIRE |
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