Meningococcal serogroup C polysaccharide specific memory B cells, directly enumerated by labeled polysaccharide, are not affected by age at vaccination
| Autor: | Maren Henneken, Einar Thoroddsen, Sigurveig T. Sigurdardottir, Nicolas Burdin, Emanuelle Trannoy, Ingileif Jonsdottir |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Adolescent Meningococcal Vaccines Neisseria meningitidis Serogroup C medicine.disease_cause Polysaccharide Microbiology Flow cytometry Young Adult medicine Humans Child chemistry.chemical_classification B-Lymphocytes Vaccines Conjugate General Veterinary General Immunology and Microbiology biology medicine.diagnostic_test Neisseria meningitidis Polysaccharides Bacterial Public Health Environmental and Occupational Health Age Factors Infant Middle Aged biology.organism_classification Virology Antibodies Bacterial Vaccination Meningococcal Infections Infectious Diseases chemistry Immunization Child Preschool Leukocytes Mononuclear Molecular Medicine Neisseriaceae Female Immunologic Memory Bacteria Conjugate |
| Zdroj: | Vaccine. 28(9) |
| ISSN: | 1873-2518 |
| Popis: | The influence of age on the generation and persistence of specific memory B cells after vaccination with Neisseria meningitidis type C polysaccharide (MenC-PS) conjugate is unknown. MenC-PS-specific B cells could be directly enumerated by fluorochrome-labeled MenC-PS and flow cytometry in blood up to at least 4 years after vaccination, ranging from 0.01% to 0.78% of total B cells and did not correlate with age at vaccination. The percentage of MenC-specific memory B cells out of total memory B cells correlated with total MenC-specific B-cells and with frequencies of IgA + plus IgG + MenC-specific AbSC, but not with MenC-specific Ab. |
| Databáze: | OpenAIRE |
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